Unusual Clinical Presentations and Diagnostic Challenges of Pediatric Ewing’s Sarcoma: A Case Series from a Tertiary Oncology Center

We present a case series of three pediatric patients diagnosed with Ewing’s sarcoma at distinct anatomical sites—the scalp with intracranial extension, the forearm involving bone, and the lumbar region with metastatic spread. Each patient underwent a detailed clinical assessment, radiological imaging, histopathology, and immunohistochemistry for diagnosis. Treatment comprised a multidisciplinary approach including surgical resection, chemotherapy, and radiotherapy. Our findings highlight the diverse clinical manifestations, diagnostic challenges, and the critical role of early detection and individualized treatment strategies in optimizing outcomes for Ewing’s sarcoma patients.