The role of lncRNA HUPCOS in androgen metabolism and follicle growth arrest in polycystic ovary syndrome
HUPCOS impairs estrogen biosynthesis in PCOS by enhancing RBPMS degradation and disrupting SMAD4-mediated transcription of CYP19 A1. These findings highlight a novel lncRNA-mediated mechanism contributing to hyperandrogenemia and follicular arrest, offering potential targets for PCOS therapy.
Authors
- Yongning Lu (ORCID: https://orcid.org/0000-0001-7172-9913)
- Yi Feng (ORCID: https://orcid.org/0000-0002-7156-6023)
- 徹 川崎
- Xiao Xu (ORCID: https://orcid.org/0000-0001-9783-6776)
- Miao Liu (ORCID: https://orcid.org/0000-0003-0912-5101)
- Suying Liu (ORCID: https://orcid.org/0000-0002-3148-2247)
- Jun Xie (ORCID: https://orcid.org/0000-0001-6023-0252)
- Yuning Chen (ORCID: https://orcid.org/0009-0007-4010-2756)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Shanghai Research Center for Acupuncture and Meridians (CN)
- Zhongshan Hospital (CN)
- China Association of Acupuncture-Moxibustion (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1007/s10565-025-10047-1
- Citations
- 1
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Natural Science Foundation of China