Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing
The proposed workflow of ZE exposure followed by HMD can provide quick and reliable data for prediction of analytical biomarkers for urinary drug screening. Following the initial identification of metabolites in ZE, human metabolites can afterwards be confirmed by HMD study. However, there are still challenges regarding HMD such as different routes of administration and detectability of applied low doses.
Authors
- Markus R. Meyer (ORCID: https://orcid.org/0000-0003-4377-6784)
- Lea Wagmann (ORCID: https://orcid.org/0000-0001-7470-7912)
- Folker Westphal (ORCID: https://orcid.org/0000-0003-0452-7814)
- Philip Schippers
- Rolf Müller (ORCID: https://orcid.org/0000-0002-1042-5665)
- Jennifer E. Herrmann (ORCID: https://orcid.org/0000-0003-3398-9938)
- Tanja M. Gampfer
- Simon K. Wellenberg
Institutions
- Helmholtz Institute for Pharmaceutical Research Saarland (DE)
- Saarland University (DE)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1002/bcp.70140
- Citations
- 1
- Primary Topic
- Forensic Toxicology and Drug Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.31