The impact of early-life exposures on growth and adult gut microbiome composition is dependent on genetic strain and parent- of- origin
Our results show that maternal exposure to nutritional deficiencies and antibiotics during gestation and lactation has a lasting impact on offspring gut microbiota composition. The specific responses to a diet or antibiotic can vary among F1 strains and may be driven by maternal genetics. Video Abstract.
Authors
- Brian J. Bennett (ORCID: https://orcid.org/0000-0002-0766-3195)
- Lisa M. Tarantino (ORCID: https://orcid.org/0000-0001-9984-2600)
- Jing Xue (ORCID: https://orcid.org/0000-0002-0146-3459)
- Keri Barron
- William Valdar (ORCID: https://orcid.org/0000-0002-2419-0430)
- M. Nazmul Huda (ORCID: https://orcid.org/0000-0003-2775-4470)
- Folami Ideraabdullah (ORCID: https://orcid.org/0000-0002-5754-2615)
- Sarah A. Schoenrock (ORCID: https://orcid.org/0000-0001-7345-444X)
- Emer Kelly
Institutions
- University College Dublin (IE)
- University of North Carolina at Chapel Hill (US)
- Western Human Nutrition Research Center (US)
- David H. Murdock Research Institute (US)
- University of California, Davis (US)
Publication Details
- Journal
- Microbiome
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s40168-025-02130-w
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- U.S. Department of Agriculture
- National Institutes of Health
- National Institute of Food and Agriculture
- University of North Carolina at Chapel Hill
- Agricultural Research Service
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Environmental Health Sciences