Conservative therapy in cervical and nasopharyngeal synchronous tumours: case report

Introduction: A 68-year-old patient was diagnosed with stage II invasive cervical squamous cell carcinoma (SCC). Case report:During staging examinations, a stage II non-keratinizing invasive nasopharyngeal SCC was identified.The patient underwent pelvic external beam radiotherapy (EBRT), followed by an external boost to the uterus, parametria, and cervical tumor and margin.Concurrently, EBRT was performed with the simultaneous integrated boost to the nasopharyngeal tumor and nodal regions.During radiotherapy, the patient received weekly chemotherapy with cisplatin, which was suspended due to hematological toxicity.Following this treatment, intrauterine and vaginal brachytherapy was performed.After 2 years of follow-up, there were not any visible lesions on both sites.Imaging studies revealed only one left cervical lymphadenopathy, with a favorable response to treatment.Conclusion: This clinical case illustrates the feasibility and efficacy of simultaneous treatment of primary cervical and nasopharyngeal stage II tumors, utilizing concurrent chemoradiotherapy, as recommended for both tumors at locally advanced stages.