HIV infection and exposure is associated with increased cariogenic taxa, reduced taxonomic turnover, and homogenized spatial differentiation for the supragingival microbiome

Despite the influence of various contributing factors, we observe an effect of HIV status on both the temporal and spatial stability of the oral microbiome. Specifically, the results presented here indicate that the oral microbiome shows less community change over time in children living with or exposed to HIV, which we hypothesize may be linked to a reduced capacity to adapt to environmental changes. The observed taxonomic rigidity among children living with HIV may signal community dysfunction, potentially leading to a higher incidence of oral diseases, including caries, in this cohort. Video Abstract.

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Publication Details

Journal
Microbiome
Published
2025-06-16
DOI
https://doi.org/10.1186/s40168-025-02123-9
Primary Topic
HIV/AIDS oral health manifestations
Type
article
Field-Weighted Citation Impact
0.00

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article

HIV infection and exposure is associated with increased cariogenic taxa, reduced taxonomic turnover, and homogenized spatial differentiation for the supragingival microbiome

Esosa Osagie, Ashlyn Soule, Paul Akhigbe, Matthew P. Rowe et al.
Microbiome
HIV/AIDS oral health manifestations
article

HIV infection and exposure is associated with increased cariogenic taxa, reduced taxonomic turnover, and homogenized spatial differentiation for the supragingival microbiome

Esosa Osagie, Ashlyn Soule, Paul Akhigbe, Matthew P. Rowe, Thomas Blouin, Allison E. Mann, Lauren M. O’Connell, Colton Kelly, Ciara Aumend, Suzanne Crull, Ozoemene Obuekwe, Augustine Omoigberale
article en

Abstract

Despite the influence of various contributing factors, we observe an effect of HIV status on both the temporal and spatial stability of the oral microbiome. Specifically, the results presented here indicate that the oral microbiome shows less community change over time in children living with or exposed to HIV, which we hypothesize may be linked to a reduced capacity to adapt to environmental changes. The observed taxonomic rigidity among children living with HIV may signal community dysfunction, potentially leading to a higher incidence of oral diseases, including caries, in this cohort. Video Abstract.

MicrobiomeVol. 13(1)
Rutgers, The State University of New Jersey (US), University of Wyoming (US), University of Florida (US), Rutgers Sexual and Reproductive Health and Rights (NL), University of Benin Teaching Hospital (NG), Institute of Human Virology (NG), University of Pennsylvania (US), Clemson University (US)
Clemson University, National Institute of Dental and Craniofacial Research
Life in Land
Openalex Percentile: Top 81%
HIV/AIDS oral health manifestations
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HIV infection and exposure is associated with increased cariogenic taxa, reduced taxonomic turnover, and homogenized spatial differentiation for the supragingival microbiome — Esosa Osagie, Ashlyn Soule, et al. · Microbiome (2025) | TGRS Research Map | TGRS