Triconnarins A–D: Four Secophragmalin-Type Limonoids from the Twigs and Leaves of <i>Trichilia connaroides</i>
Four novel secophragmalin-type limonoids, triconnarins A-D (<b>1</b>-<b>4</b>), have been identified from the small branches and leaves of <i>Trichilia connaroides</i>. Triconnarin A (<b>1</b>) featured an unprecedented 5/6/4/6/6 ring skeleton, which belonged to the rare 1,10-secophragmalin classes. Triconnarin B (<b>2</b>) was the first B-ring opening secophragmalin limonoid, whereas triconnarin C (<b>3</b>) possessed a unique 5/5-6/6 ring system. Compounds <b>1</b>-<b>3</b> were proven to demonstrate potent QR-inducing activity.
Authors
- Jian‐Min Yue (ORCID: https://orcid.org/0000-0002-4053-4870)
- Jiaxin Xu (ORCID: https://orcid.org/0000-0002-6797-1413)
- Tao Shen (ORCID: https://orcid.org/0000-0002-5474-2646)
- Haiyang Zhao (ORCID: https://orcid.org/0000-0002-5786-7380)
- Dong‐Mei Ren (ORCID: https://orcid.org/0000-0002-1717-2429)
- Xiao‐Ning Wang (ORCID: https://orcid.org/0000-0001-5032-5135)
- Zhiying Li (ORCID: https://orcid.org/0000-0002-4720-2713)
- Xiaozhou Li (ORCID: https://orcid.org/0000-0003-3882-7073)
Institutions
- Shandong University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- State Key Laboratory of Drug Research
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1021/acs.orglett.4c04459
- Citations
- 1
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China