Targeting neuroinflammation: 3-monothiopomalidomide a new drug candidate to mitigate traumatic brain injury and neurodegeneration
3-MP represents a promising new class of thalidomide-like IMiDs with potent anti-inflammatory effects that offers potential for treating TBI and possibly other neurodegenerative diseases possessing a prominent neuroinflammatory component.
Authors
- Ross A. McDevitt (ORCID: https://orcid.org/0000-0003-3722-9047)
- Chirag Patel (ORCID: https://orcid.org/0000-0003-0777-7720)
- Abdul Mannan Baig (ORCID: https://orcid.org/0000-0003-0626-216X)
- David Tweedie (ORCID: https://orcid.org/0000-0002-8446-4544)
- Anna R. Carta (ORCID: https://orcid.org/0000-0003-3104-9010)
- Shih‐Chang Hsueh (ORCID: https://orcid.org/0009-0002-0838-0223)
- Nigel H. Greig (ORCID: https://orcid.org/0000-0002-3032-1468)
- Weiming Luo (ORCID: https://orcid.org/0009-0002-3035-3176)
- Ju‐Wan Kim (ORCID: https://orcid.org/0000-0002-9888-1090)
- Neil Vargesson (ORCID: https://orcid.org/0000-0001-8027-114X)
- Buyandelger Batsaikhan (ORCID: https://orcid.org/0000-0002-1505-9334)
- Yu Kyung Kim (ORCID: https://orcid.org/0000-0002-4699-8502)
- Pathik Parekh (ORCID: https://orcid.org/0000-0002-4385-751X)
- Mee Youn Lee
- Barry J. Hoffer (ORCID: https://orcid.org/0000-0002-1122-9025)
- Dong Liu (ORCID: https://orcid.org/0000-0003-0451-5979)
- Sun Kim (ORCID: https://orcid.org/0000-0003-3072-6649)
- Dong Seok Kim (ORCID: https://orcid.org/0000-0001-5637-2469)
- Inho Hwang (ORCID: https://orcid.org/0000-0003-2039-3895)
- Warren R. Selman
Institutions
- National Institute on Drug Abuse (US)
- University of Cagliari (IT)
- University of Aberdeen (GB)
- Quality Biological (US)
- Baptist Health South Florida (US)
- RED Consulting (Norway) (NO)
- National Institute on Aging (US)
- Schön Klinik Bad Aibling (DE)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s12929-025-01150-w
- Citations
- 4
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Institutes of Health
- National Institute on Aging