Detecting monogenic obesity: a systematic exome-wide workup of over 500 individuals
Overall, 12.9% of patients had monogenic obesity or a potentially obesogenic variant. These findings suggest that genetic testing should not be limited to patients with extreme obesity. Current obesity panels miss crucial syndromic genes, demonstrating a need for more comprehensive panels and the superiority of whole-exome sequencing in obesity.
Authors
- Antje Garten (ORCID: https://orcid.org/0000-0002-5354-287X)
- Robert H. Stein
- Diana Le Duc (ORCID: https://orcid.org/0000-0001-7289-2552)
- H. Faust (ORCID: https://orcid.org/0009-0005-2853-341X)
- E. Wenzel (ORCID: https://orcid.org/0000-0003-2814-5634)
- Albrecht Kobelt
- Denny Popp (ORCID: https://orcid.org/0000-0001-5656-2027)
- Johannes R. Lemke (ORCID: https://orcid.org/0000-0002-4435-6610)
- Linnaeus Bundalian (ORCID: https://orcid.org/0009-0004-7460-4330)
- Torsten Schöneberg (ORCID: https://orcid.org/0000-0001-5313-0237)
- Mariami Jasaszwili (ORCID: https://orcid.org/0000-0002-2821-5076)
- Matthias Blüher (ORCID: https://orcid.org/0000-0003-0208-2065)
- Antje Körner (ORCID: https://orcid.org/0000-0001-6001-0356)
- Rami Abou Jamra (ORCID: https://orcid.org/0000-0002-1542-1399)
- Anna Sophia Kirstein (ORCID: https://orcid.org/0000-0002-3554-1902)
- Robert Künzel
Institutions
- Helmholtz Zentrum München (DE)
- University Hospital Leipzig (DE)
- German Centre for Cardiovascular Research (DE)
- Klinikum Chemnitz (DE)
- Leipzig University (DE)
Publication Details
- Journal
- International Journal of Obesity
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1038/s41366-025-01819-0
- Citations
- 5
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- Deutsche Forschungsgemeinschaft