Diseases Common in Persons With Cystic Fibrosis Among <i>CFTR</i> Heterozygotes
In this genetic association study, most heterozygotes did not appear to have a substantially higher risk of cystic fibrosis-associated diseases during their adulthood compared to noncarriers. Additional studies are needed to investigate the underlying factors for the elevated risk of respiratory and infectious diseases in some heterozygotes.
Authors
- Karen S. Raraigh (ORCID: https://orcid.org/0000-0001-6730-6854)
- Tam C. Tran
- Chenjie Zeng (ORCID: https://orcid.org/0000-0002-0149-5661)
- Sangwoo T. Han (ORCID: https://orcid.org/0000-0002-5876-704X)
- Thomas Cassini (ORCID: https://orcid.org/0000-0002-3522-2135)
- Garry R. Cutting (ORCID: https://orcid.org/0000-0002-8250-8590)
- Joshua C. Denny (ORCID: https://orcid.org/0000-0002-3049-7332)
- James C. Yang (ORCID: https://orcid.org/0000-0001-8935-5008)
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- National Human Genome Research Institute (US)
- New York Genome Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- JAMA Internal Medicine
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1001/jamainternmed.2025.1853
- Citations
- 1
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.52