To reveal the key mechanism of Citri Reticulatae Pericarpium–Reynoutria japonica Houtt in the treatment of liver cancer and its correlation with lipid metabolism: synergetic effect with network pharmacology, molecular docking and bioinformatics
Survival analysis indicated that HSP90AA1 may serve as a potential biomarker for LC. Molecular docking studies showed that rhein, a compound in CR, has a strong binding affinity to the identified target proteins. This research provides robust theoretical support for the clinical application of CR in treating LC, especially in cases related to non-alcoholic fatty liver disease (NAFLD) or Metabolic Lipid Disorders (DLM).
Authors
- Yifeng Wang (ORCID: https://orcid.org/0009-0004-6557-714X)
- Xiao Lin (ORCID: https://orcid.org/0000-0003-3794-346X)
- Chun-Hong Gu
- Yueming Ma (ORCID: https://orcid.org/0000-0001-7701-0846)
- Yujie Wang (ORCID: https://orcid.org/0000-0001-5830-2341)
- Lin Chen (ORCID: https://orcid.org/0000-0002-1454-8275)
- Jia‐Hao Zhou (ORCID: https://orcid.org/0000-0001-8874-7405)
- Jianyi Wang (ORCID: https://orcid.org/0000-0003-3917-8327)
- Chufan Ren
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Yueyang Hospital (CN)
- Zhejiang University of Finance and Economics (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1007/s12672-025-02708-8
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission