BLADDER CANCER OR AMYLOIDOSIS OF THE BLADDER? CHALLENGES IN DIAGNOSIS AND MANAGEMENT

Primary bladder amyloidosis is a rare condition involving the extracellular deposition of amyloid proteins in the bladder.This localized form is unusual in the urinary system and often mimics urothelial carcinoma, creating diagnostic challenges due to similar clinical and imaging characteristics.Given its rarity and potential for misdiagnosis, we present a case of recurrent primary bladder amyloidosis and insights from a systematic review to improve understanding of this challenging disease.A systematic literature review was conducted in October 2024 following PRISMA guidelines, focusing on recurrence rates, treatment outcomes, and follow-up strategies in bladder amyloidosis cases.Searches were performed in PubMed, Embase, and Cochrane CENTRAL.Additionally, we retrospectively analyzed the case of a patient presenting with multifocal bladder amyloidosis and recurrent hematuria.