4-Octyl itaconate alleviates endothelial cell inflammation and barrier dysfunction in LPS-induced sepsis via modulating TLR4/MAPK/NF-κB signaling
4-OI protects against sepsis-induced vascular injury and tissue damage by suppressing endothelial inflammation, oxidative stress, and preserving endothelial barrier integrity.
Authors
- Chunxiang Zhang (ORCID: https://orcid.org/0000-0001-8303-6495)
- Jiajia Rao (ORCID: https://orcid.org/0000-0003-4253-269X)
- Jianbo Wu (ORCID: https://orcid.org/0000-0003-3319-9717)
- Yi Zhou (ORCID: https://orcid.org/0000-0003-4543-3099)
- Haoran Wu (ORCID: https://orcid.org/0000-0003-3560-6478)
- Yan Yang (ORCID: https://orcid.org/0000-0001-5200-7309)
- Xiao Zhang (ORCID: https://orcid.org/0000-0002-8054-0968)
- Zhichao Li (ORCID: https://orcid.org/0000-0002-5314-2112)
- Rong Li (ORCID: https://orcid.org/0000-0001-6159-3987)
- Liqun Wang (ORCID: https://orcid.org/0000-0003-3362-0444)
- Xiaoqin Zhang (ORCID: https://orcid.org/0000-0003-0958-7285)
- Yi Wan (ORCID: https://orcid.org/0000-0003-1312-6254)
- Nianhui Ding (ORCID: https://orcid.org/0009-0005-5310-5257)
- Yu Ma
- Xin Hu
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Xiyuan Hospital (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s10020-025-01160-2
- Citations
- 17
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 13.56
Funders
- National Natural Science Foundation of China
- Sichuan Province Science and Technology Support Program