Sex differences in resting skeletal muscle and the acute and long-term response to endurance exercise in individuals with overweight and obesity
Our findings highlight sex-specific molecular signatures that reflect known differences in glucose and lipid metabolism between female and male skeletal muscle. After just 8 weeks of endurance training, these sex differences were attenuated, suggesting a convergence towards a shared beneficial adaptation at the molecular level.
Authors
- Martin Hrabě de Angelis (ORCID: https://orcid.org/0000-0002-7898-2353)
- Andreas L. Birkenfeld (ORCID: https://orcid.org/0000-0003-1407-9023)
- Miriam Hoene (ORCID: https://orcid.org/0000-0001-7014-1501)
- Andreas Peter (ORCID: https://orcid.org/0000-0001-5732-2287)
- Stefanie M. Hauck (ORCID: https://orcid.org/0000-0002-1630-6827)
- Christine von Toerne (ORCID: https://orcid.org/0000-0002-4132-4322)
- Cora Weigert (ORCID: https://orcid.org/0000-0003-0358-776X)
- Meriem Ouni (ORCID: https://orcid.org/0000-0002-7781-8463)
- Annette Schürmann (ORCID: https://orcid.org/0000-0002-4113-4377)
- Thomas Goj (ORCID: https://orcid.org/0000-0002-3075-0588)
- Markus Jähnert (ORCID: https://orcid.org/0000-0001-6459-7318)
- Martin Irmler (ORCID: https://orcid.org/0000-0003-3169-479X)
- Anja Moller (ORCID: https://orcid.org/0000-0002-5344-8533)
- Simon I. Dreher (ORCID: https://orcid.org/0000-0002-8266-1624)
- Johannes Beckers (ORCID: https://orcid.org/0000-0001-7874-3822)
Institutions
- Helmholtz Zentrum München (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- Heinrich Heine University Düsseldorf (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1016/j.molmet.2025.102185
- Citations
- 6
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 6.91
Funders
- Bundesministerium für Bildung und Forschung