Abdominal tuberculosis in a patient with ankylosing spondylitis and infliximab: is the risk still too great? A case report

Ankylosing spondylitis is a chronic inflammatory spondyloarthropathy that will cause severe symptoms and complications if left untreated. Anti-TNF-α inhibitor is the treatment of choice, yet all treatments have difficulties, and opportunistic infections following this therapy are well known. Reactivation of latent tuberculosis (TB) and abdominal TB is a serious problem in this therapy since diagnosis is difficult, as symptoms are nonspecific, and complications can be fatal. We present the case of a 47-year-old female doctor with a past medical history of ankylosing spondylitis; she was treated with infliximab. She began developing abdominal pain that led to an acute abdomen due to abdominal TB. After successful treatment, she fully recovered, and the patient is doing well in follow-ups.

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Publication Details

Journal
Journal of Surgical Case Reports
Published
2025-05-31
DOI
https://doi.org/10.1093/jscr/rjaf422
Primary Topic
Infectious Diseases and Tuberculosis
Type
article
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article

Abdominal tuberculosis in a patient with ankylosing spondylitis and infliximab: is the risk still too great? A case report

Gabriel A Molina, T. Borja, María Teresa Magaña‐Torres, Miguel A Moyón et al.
Journal of Surgical Case Reports
Infectious Diseases and Tuberculosis
article

Abdominal tuberculosis in a patient with ankylosing spondylitis and infliximab: is the risk still too great? A case report

Gabriel A Molina, T. Borja, María Teresa Magaña‐Torres, Miguel A Moyón, Natali Moyón, Johan Stephany Añazco, Alex Enrique Vásconez, David Larreategui
article en

Abstract

Ankylosing spondylitis is a chronic inflammatory spondyloarthropathy that will cause severe symptoms and complications if left untreated. Anti-TNF-α inhibitor is the treatment of choice, yet all treatments have difficulties, and opportunistic infections following this therapy are well known. Reactivation of latent tuberculosis (TB) and abdominal TB is a serious problem in this therapy since diagnosis is difficult, as symptoms are nonspecific, and complications can be fatal. We present the case of a 47-year-old female doctor with a past medical history of ankylosing spondylitis; she was treated with infliximab. She began developing abdominal pain that led to an acute abdomen due to abdominal TB. After successful treatment, she fully recovered, and the patient is doing well in follow-ups.

Journal of Surgical Case ReportsVol. 2025(6)
Vidant Health (US), Pontificia Universidad Católica del Ecuador (EC), Clinique Pasteur (FR), Universidad San Francisco de Quito (EC)
Good health and well-being
Openalex Percentile: Top 76%
Infectious Diseases and Tuberculosis
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