Quercetagetin alleviates liver fibrosis in non-alcoholic fatty liver disease by promoting ferroptosis of hepatic stellate cells through GPX4 ubiquitination
QG, the active ingredient of HGTLF, can induce ferroptosis of HSCs by targeting the degradation of GPX4 through ubiquitination and inhibit HSC activation, thereby alleviating liver fibrosis in NAFLD.
Authors
- Mingzuo Jiang
- Xi Chen (ORCID: https://orcid.org/0000-0002-2634-8641)
- Ang Huang (ORCID: https://orcid.org/0000-0001-8876-9903)
- Yuping Qiu (ORCID: https://orcid.org/0000-0002-1160-2256)
- Zhizhou Yang
- Hui Li (ORCID: https://orcid.org/0000-0002-5604-0592)
- Juan Wei
- Ya Yang
- Ji Xuan (ORCID: https://orcid.org/0009-0001-7402-4158)
- Shupei Li
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese PLA General Hospital (CN)
- Jinling Institute of Technology (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s13020-025-01109-x
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Beijing Nova Program