Inactivation of RhoA for Hypertension Treatment Through the TRPV4–RhoA–RhoGDI1 Axis
This study revealed a novel mode of RhoA signaling inhibition targeting the TRPV4-RhoA-RhoGDI1 axis, offering new insights for future antihypertensive drug development and proposing innovative strategies for targeting challenging Rho GTPases.
Authors
- Jianjun Fu (ORCID: https://orcid.org/0000-0001-9792-002X)
- Luyao Qi (ORCID: https://orcid.org/0009-0005-3723-7452)
- Bowen Ke (ORCID: https://orcid.org/0000-0002-0328-7719)
- Jiwei Shan (ORCID: https://orcid.org/0009-0004-3407-7257)
- Honglei Zhou (ORCID: https://orcid.org/0000-0003-2551-4641)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-0520-3275)
- Yufang F. Xu (ORCID: https://orcid.org/0000-0003-4946-4722)
- Xuhong Qian (ORCID: https://orcid.org/0000-0003-0394-1968)
- Wenjie Liao
- Rui Wang (ORCID: https://orcid.org/0000-0001-7209-741X)
- Honglin Li (ORCID: https://orcid.org/0000-0003-2270-1900)
- Tiejun Li (ORCID: https://orcid.org/0000-0002-6877-9693)
- Na Yu (ORCID: https://orcid.org/0000-0002-6603-1702)
- Zhen Yuan (ORCID: https://orcid.org/0000-0001-7106-4632)
- Ya Mo (ORCID: https://orcid.org/0000-0001-5799-645X)
- Zhenjiang Zhao (ORCID: https://orcid.org/0000-0002-9706-6158)
- Shiliang Li (ORCID: https://orcid.org/0000-0003-4414-237X)
- Qian Jiao (ORCID: https://orcid.org/0009-0003-0576-8297)
- Shanshan Ruan
- Yi Zhao (ORCID: https://orcid.org/0009-0007-0678-4458)
- Jiawen Wang (ORCID: https://orcid.org/0000-0003-0245-1449)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Shanghai Jian Qiao University (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1161/circulationaha.124.071884
- Citations
- 5
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 5.60