Comparative Effectiveness of Levofloxacin-Based Triple Regimen and Standard Clarithromycin-Based Triple Regimen in Eradication of Helicobacter Pylori - Insights from A Peripheral Hospital-Based Study

Objective: To compare the effectiveness of a Levofloxacin-based triple regimen with the standardClarithromycin-based triple regimen in eradicating gastric Helicobacter pylori (H. pylori) infection.Study Design: Quasi-experimental study.Place and Duration of Study: This study was conducted at the Department of Medicine, Combined MilitaryHospital (CMH), Sibbi, Pakistan from January 2021 to August 2022.Methods: A total of two hundred and sixty patients (n=260), both male and female, diagnosed with H. pyloriinfection, were enrolled. Patients who had used antibiotics within the past four weeks or proton pumpinhibitors within the past two weeks were excluded to avoid interference with treatment efficacy. Participantswere randomly assigned to two groups: The Levofloxacin Group received levofloxacin, amoxicillin, andomeprazole, while the Clarithromycin Group was treated with clarithromycin, amoxicillin, and omeprazole,each regimen lasting 14 days. After completing the eradication therapy, all patients were assessed for H. pylorieradication using the fecal antigen test.Results: The median age of the participants was 30.00 years (26.00–36.00). Of the patients, 158 (60.8%) werefemale and 102 (39.2%) were male. Post-treatment testing revealed that 209 patients (80.4%) tested negative,indicating successful eradication, while 51 patients (19.6%) remained positive for fecal H. pylori antigen test. Inthe Clarithromycin Group, 96 patients (73.8%) tested negative, compared to 113 patients (86.9%) in theLevofloxacin Group, showing a statistically significant difference (P = 0.008).Conclusion: The Levofloxacin-based triple therapy regimen proved significantly more effective in eradicatingHelicobacter pylori infection than the standard Clarithromycin-based triple therapy regimen, suggesting itspotential as a valuable first-line alternative, particularly in regions with high Clarithromycin resistance. How to cite this: Ahmad I, Bano K, Shabbir K, Razzaq K, Khan RSA, Iqbal Q. Comparative Effectiveness of Levofloxacin Based Triple Regimen and Standard Clarithromycin Based Triple Regimen in Eradication of Helicobacter Pylori - Insights from A Peripheral Hospital- Based Study. Life and Science. 2025; 6(2): 236-241. doi: http://doi.org/10.37185/LnS.1.1.341