Mean Platelet Volume as a Non-Invasive Marker of Liver Fibrosis in Patients with Chronic Hepatitis B: A Multicenter Study from Rawalpindi and Quetta

Objective: To determine the mean platelet volume as a noninvasive marker of liver fibrosis in patients withchronic hepatitis B.Study Design: Prospective observational study.Place and Duration of Study: This study was conducted at the Department of Gastroenterology, CombinedMilitary Hospital (CMH), Quetta and Pak Emirates Military Hospital (PEMH), Rawalpindi, Pakistan from August2023 to April 2024.Methods: A total of 132 hepatitis B patients reported to the Department of Gastroenterology were included inthe study. Convenience sampling was performed. The platelet count, Mean platelet volume, and haemoglobinlevel were assessed. After a Transient Elastography (Fibroscan), fibrosis and chronicity indices were comparedto the patient haematological parameter, Mean Platelet Volume, and the accuracy and consistency ofhaematological values in predicting hepatic fibrosis were investigated. Version 26.0 of the Statistical Packagefor the Social Sciences was used for data entry and analysis. An independent t-test was applied betweengroups.Results: Among the total of 132 patients, 86 were male and 46 were female. Subjects were separated into twocohorts, each consisting of 66 patients matched in age and gender. Group A with fibrosis grades F0, F1, and F2and group B with F3 and F4. The mean platelet volume was determined in each group. Group A had a MeanPlatelet Volume (10.456 + 0.922 femtolitre). Group B had a Mean Platelet Volume of (12.745+ 1.049 femtolitre).There were statistically significant variations in Mean Platelet Volume across the groups, as shown by anindependent sample t-test (P<0.01).Conclusion: MPV is a noninvasive indicator of liver fibrosis in chronic hepatitis B patients. We suggest that MPVcould be helpful in evaluating fibrosis in these patients. Because a stand-alone test is nonspecific concerningother illnesses, it should not be considered for this purpose. How to cite this: Ahmad MI, Ahmad I, Khan FR, Nasir JA, Hannan A, Nisa Q. Mean Platelet Volume as a Non-Invasive Marker of Liver Fibrosis in Patients with Chronic Hepatitis B: A Multicenter Study from Rawalpindi and Quetta. Life and Science. 2025; 6(2): 196-201. doi: http://doi.org/10.37185/LnS.1.1.782