Efficacy of CDK4/6 Inhibition in colorectal cancer and the role of p16 expression in predicting drug resistance
Ribociclib demonstrates significant antitumoral effects across a large panel of cancer cell lines and chemoresistant models, especially in CRC. Resistance towards ribociclib is associated with high p16 expression, which is a negative prognostic marker for patients with CRC. Our findings underscore p16 as a promising biomarker for predicting ribociclib responsiveness and emphasize the need for further mechanistic studies and combination therapy approaches to overcome resistance in p16<sup>high</sup> patients.
Authors
- Ralf Wimmer (ORCID: https://orcid.org/0000-0002-8596-0574)
- Florian Paul Reiter (ORCID: https://orcid.org/0000-0003-3807-1456)
- Heike M. Hermanns (ORCID: https://orcid.org/0000-0002-6617-1668)
- Julia V. Mayerle (ORCID: https://orcid.org/0000-0002-3666-6459)
- Najib Ben Khaled (ORCID: https://orcid.org/0000-0002-9681-2542)
- Jan Neuman
- Solveig Kuss (ORCID: https://orcid.org/0000-0002-2363-8475)
- Ujjwal Mukund Mahajan (ORCID: https://orcid.org/0000-0002-7238-8775)
- Monika Rau
- Gerald Denk
- Andreas Geier (ORCID: https://orcid.org/0000-0002-9626-5083)
- Enrico Narciso De Toni (ORCID: https://orcid.org/0000-0002-8101-8207)
- Alexander Weich (ORCID: https://orcid.org/0000-0002-4127-1347)
- Jörg Kumbrink (ORCID: https://orcid.org/0000-0003-4633-4105)
- Volker Kunzmann (ORCID: https://orcid.org/0000-0002-3615-7566)
- Linda Hammann
- Julia Schneider
- Liangtao Ye (ORCID: https://orcid.org/0000-0003-4364-9494)
- Christoph Suppan (ORCID: https://orcid.org/0000-0003-0284-3848)
Institutions
- Sun Yat-sen University (CN)
- Medical University of Graz (AT)
- LMU Klinikum (DE)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- National Institute of Pharmaceutical Education and Research - Ahmedabad (IN)
- Universitätsklinikum Würzburg (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1007/s13402-025-01080-7
- Citations
- 2
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 3.04