The antioxidant and therapeutic effects of Malva sylvestris extract on testicular tissue and sperm quality in varicocele-induced adult Wistar rats
Based on the findings, Malva sylvestris as cytoprotective agent modulate key antioxidant pathways, including upregulation of SIRT1 and FOXO1 (linked to cellular repair and OS resistance) and downregulation of pro-inflammatory mediators; then, Malva sylvestris as a promising natural antioxidant for managing varicocele-related infertility, offering a potential adjunct or alternative to conventional therapies.
Authors
- Mahnaz Azarnia (ORCID: https://orcid.org/0000-0001-5426-9302)
- Latifeh Karimzadeh (ORCID: https://orcid.org/0000-0001-7420-6392)
- Fatemeh Koohkan
Institutions
- Kharazmi University (IR)
Publication Details
- Journal
- Basic and Clinical Andrology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s12610-025-00271-4
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kharazmi University