Study on Point Selection Rule of Acupuncture Treatment for Cancer-Related Fatigue in Breast Cancer Based on Data Mining

目的：基于数据挖掘探讨针刺治疗乳腺癌癌因性疲乏的取穴规律。方法：检索中国知网、万方、维普、中国生物医学文献数据库、PubMed数据库2024年12月之前的文献，收集相关针刺治疗乳腺癌癌因性疲乏的临床文献，提取穴位处方，建立数据库，统计穴位频数及归经，进行穴位关联规则分析及聚类分析。结果：共录入30篇文献，涉及71个穴位，所有用穴总频次为233。频次最高的8个腧穴为：足三里、三阴交、气海、关元、内关、百会、合谷、太冲。腧穴归经以足阳明胃经、足太阴脾经和督脉用穴最多。关联规则分析得出1条强链接：足三里–三阴交。聚类分析得到5个聚类组分别为：足三里–三阴交–气海–关元–百会；血海–膈俞–肾俞；中脘–脾俞–内关；神门–太渊–悬钟；合谷–太冲–太溪–印堂。结论：以足三里–三阴交为核心，针刺治疗乳腺癌癌因性疲乏的选穴体现了“虚则补之”“调神固本”的辨证论治思想。主要治则为补脾胃、温肾阳、疏肝气，展现出针刺治疗乳腺癌癌因性疲乏的特色疗法：在补虚治疗基础上加以调神疏肝。Objective: To explore the point selection rule in acupuncture treatment for cancer-related fatigue (CRF) in breast cancer using data mining. Methods: Literature published before December 2024 was retrieved from databases including CNKI, Wanfang, VIP, China Biology Medicine (CBM), and PubMed. Clinical studies on acupuncture treatment for CRF in breast cancer were collected, and acupoint prescriptions were extracted to establish a database. To analyze the frequency and meridian distribution of acupoints. Association rule analysis was performed, and cluster analysis was conducted. Results: A total of 30 articles were included, involving 71 acupoints with a cumulative frequency of 233. The eight most frequently used acupoints were Zusanli, Sanyinjiao, Qihai, Guanyuan, Neiguan, Baihui, Hegu, and Taichong. Acupoints were primarily distributed in the Stomach Meridian of Foot-Yangming, Spleen Meridian of Foot-Taiyin, and Governor Vessel. Association rule analysis revealed one strong link: Zusanli-Sanyinjiao and five moderate links: Zusanli-Sanyinjiao-Qihai- Guanyuan-Baihui; Xuehai-Geshu-Shenshu; Zhongwan-Pishu-Neiguan; Shenmen-Taiyuan-Xuanzhong; Hegu-Taichong-Taixi-Yintang. Conclusion: The core acupoint combination is Zusanli-Sanyinjiao, reflecting the principles of “reinforcing method for deficiency syndrome” and “regulating spirit and consolidating foundation” in traditional Chinese medicine (TCM) syndrome differentiation. The primary treatment principles involve tonifying the spleen and stomach, warming kidney yang, and soothing liver qi. This highlights the characteristic therapeutic approach of acupuncture in managing breast cancer-related fatigue: integrating spirit-regulation and liver-soothing techniques on the foundation of deficiency-tonifying treatment.