One-pot synthesis of sulfonylmethyl phthalides <i>via</i> K <sub>2</sub> S <sub>2</sub> O <sub>8</sub> /DMSO-mediated methylenylation/sulfonylation of eudesmic acid with sulfinates
A K<sub>2</sub>S<sub>2</sub>O<sub>8</sub>/DMSO-mediated one-pot reaction of eudesmic acid with sodium sulfinates was developed for the synthesis of various sulfonylmethyl trioxygenated phthalides <i>via</i> double methylenation and sulfonylation pathways. In this effective reaction, dimethyl sulfoxide was used as both a solvent and a methylene source through the formation of one carbon-sulfur single bond, one carbon-oxygen single bond, and two carbon-carbon single bonds under open-vessel conditions.
Authors
- Chung‐Jen Ou (ORCID: https://orcid.org/0000-0002-8688-6185)
- Meng‐Yang Chang (ORCID: https://orcid.org/0000-0002-1983-8570)
Institutions
- Kaohsiung Medical University (TW)
- National Pingtung University of Science and Technology (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00632e
- Citations
- 2
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.87