P34 Non-systemic treatment of metastatic kidney cancer

Introduction & Objectives: To date, there is insufficient literature on the local treatment options for metastatic renal cell carcinoma (mRCC). Various options, such as metastasectomy, thermal ablation, and stereotactic body radiotherapy, have gained attention for their potential to improve survival and quality of life in selected patients' groups. Materials & Methods: A systematic review of studies published since 2009 was conducted, following PRISMA guidelines. Relevant articles were identified from PubMed and ScienceDirect databases, using search terms related to mRCC and non-systemic treatment. Additionally, a case report was included in the article, documenting the successful use of cryoablation in controlling metastases of kidney cancer. Results: Thirteen studies met the inclusion criteria. Complete metastasectomy demonstrated improved overall survival (OS) and progressionfree survival (PFS) compared to incomplete or no metastasectomy. Stereotactic body radiotherapy (SBRT) and other forms of radiotherapy provided effective palliation and durable disease control. However, combining systemic therapy with local treatment modalities yielded mixed outcomes, indicating the need for further studies. Conclusions: This systematic review highlights the potential survival benefits for mRCC patients with the use of different local treatment modalities, especially in terms of complete metastasectomy. The findings show the need for continued research to optimize local treatment strategies and improve patient outcomes.