Validation of PREdiction of DELIRium in ICu patients (PRE-DELIRIC) model for ICU delirium in general ICU and patients with liver disease: a retrospective cohort study

This is the largest validation study of the PRE-DELIRIC model to date, and the first to specifically consider patients with liver disease. We found moderate-to-good discriminative predictive performance both overall and in liver disease patients, but calibration was only moderate overall, and significantly under-predicted risk in patients with liver disease. Recalibration of the model and further subgroup-specific adjustments may enhance its utility in clinical practice.