The phenomenology of psilocybin’s experience mediates subsequent persistent psychological effects independently of sex, previous experience, or setting
Repeated psilocybin administration in healthy individuals induces positive, lasting effects, with challenging experiences in controlled settings not causing adverse outcomes. These findings support psilocybin's psychological safety and its repeated use in clinical trials.
Authors
- Kateřina Hájková (ORCID: https://orcid.org/0000-0002-5828-2472)
- Čestmír Vejmola (ORCID: https://orcid.org/0000-0002-6434-5978)
- M. Nikolič (ORCID: https://orcid.org/0000-0002-2564-7287)
- Jakub Korčák (ORCID: https://orcid.org/0000-0001-5017-4736)
- Jiřı́ Horáček (ORCID: https://orcid.org/0000-0003-0114-7306)
- Tereza Klučková (ORCID: https://orcid.org/0009-0008-0335-6201)
- Michaela Viktorinová (ORCID: https://orcid.org/0000-0002-6462-5793)
- Veronika Andrashko (ORCID: https://orcid.org/0000-0001-5488-3345)
- Renáta Androvičová (ORCID: https://orcid.org/0000-0002-1099-0891)
- Tomáš Páleníček (ORCID: https://orcid.org/0000-0002-3109-9539)
- Anna Bravermanová (ORCID: https://orcid.org/0000-0003-4503-7061)
- Martin Brunovský (ORCID: https://orcid.org/0000-0002-2483-0848)
- Martin Kuchař (ORCID: https://orcid.org/0000-0002-7616-6352)
- Marie Balı́ková (ORCID: https://orcid.org/0000-0001-6334-1177)
- Peter Zach
- Vojtěch Viktorin (ORCID: https://orcid.org/0000-0003-0801-2244)
- Filip Tylš (ORCID: https://orcid.org/0000-0001-7656-1224)
Institutions
- Charles University (CZ)
- National Institute of Mental Health (JP)
- National Institute of Mental Health (CZ)
- University of Chemistry and Technology, Prague (CZ)
Publication Details
- Journal
- Pharmacological Reports
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1007/s43440-025-00742-5
- Citations
- 2
- Primary Topic
- Psychedelics and Drug Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Univerzita Karlova v Praze
- Grantová Agentura České Republiky
- Ministerstvo Zdravotnictví Ceské Republiky
- Agentura Pro Zdravotnický Výzkum České Republiky
- European Regional Development Fund