Mediating role of Interleukin-6 in the predictive association of diabetes with Hippocampus atrophy, Amyloid, Tau, and Neurofilament pathology at pre-clinical stages of diabetes-related cognitive impairment
The study captured a pre-clinical stage of the T<sub>2</sub>DM-dementia association. The mediating effect of IL-6 is a novelty that has to be further explored and accounted for in risk stratification and preventive measures, particularly in ethnic minorities.
Authors
- Asma Hallab (ORCID: https://orcid.org/0000-0002-3901-7980)
Institutions
- Humboldt-Universität zu Berlin (DE)
- Sorbonne Université (FR)
- Laboratoire de Biologie Intégrative des Modèles Marins (FR)
- Massachusetts General Hospital (US)
- Pitié-Salpêtrière Hospital (FR)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1016/j.bbih.2025.101031
- Citations
- 3
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Institutes of Health
- National Institute on Aging