Comparison of recurrence patterns between patients with thoracic esophageal squamous cell carcinoma treated with neoadjuvant chemoradiotherapy and postoperative adjuvant chemoradiotherapy
There was significant difference in the OS and DFS prognosis of patients with ESCC treated with NCRT and ACRT. Recurrence primarily occurs within 2 years following esophagectomy. The recurrence rate was higher in the NCRT group compared to the ACRT group. Patients with early recurrence had a poorer survival prognosis compared to those with late recurrence. Pathological N staging was identified as an independent risk factor affecting OS in the NCRT group. Furthermore, margin status and pathological T staging were independent risk factors influencing OS in the ACRT group.
Authors
- Xuefeng Leng (ORCID: https://orcid.org/0000-0002-5897-0419)
- Haojun Li (ORCID: https://orcid.org/0000-0003-0318-6528)
- Longlin Jiang
- Qiang Fang (ORCID: https://orcid.org/0000-0003-2518-745X)
- Guangyuan Liu (ORCID: https://orcid.org/0000-0002-8058-5947)
- Yixuan Huang (ORCID: https://orcid.org/0000-0003-2162-4544)
- Wenwu He (ORCID: https://orcid.org/0000-0002-2477-9587)
- Huan Zhang (ORCID: https://orcid.org/0009-0009-1420-0154)
- Lin Peng
- Jialong Li (ORCID: https://orcid.org/0000-0001-8950-3138)
- Yongtao Han (ORCID: https://orcid.org/0000-0001-9165-9297)
- Qiang Zhou (ORCID: https://orcid.org/0000-0002-7978-6602)
- Kangning Wang (ORCID: https://orcid.org/0000-0001-6690-0149)
- Kunhan Ni
- Simiao Lu
- Chenghao Wang (ORCID: https://orcid.org/0000-0003-0641-6405)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- Sichuan Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.3389/fonc.2025.1604808
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Chengdu Science and Technology Bureau
- Key Research and Development Program of Sichuan Province