Intracellular self-assembly and metabolite analysis of key enzymes for L-lysine synthesis based on key components of cellulosomes
This strategy exerts the "proximity effect" among multi-enzyme complexes, improves the transfer efficiency of intermediate metabolites between different catalytic active centers, indirectly improves the catalytic rate of each key enzyme, and provides a novel idea and technical platform for other multi-enzyme intracellular assemblies.
Authors
- Bowen Du
- Piwu Li (ORCID: https://orcid.org/0000-0002-2134-4641)
- Nan Li (ORCID: https://orcid.org/0000-0002-8248-9027)
- Junqing Wang (ORCID: https://orcid.org/0000-0001-9862-2366)
- Peng Du (ORCID: https://orcid.org/0000-0002-3466-8020)
- Junlin Li (ORCID: https://orcid.org/0000-0002-3204-6420)
- Jing Xiao (ORCID: https://orcid.org/0000-0002-0573-8106)
- Lu Yang (ORCID: https://orcid.org/0009-0007-3751-8996)
- Ruiming Wang (ORCID: https://orcid.org/0009-0008-9902-0875)
- Xiankun Ren
Institutions
- Qilu University of Technology (CN)
- Kai Biotech (South Korea) (KR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.3389/fmicb.2025.1596240
- Citations
- 2
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- China Postdoctoral Science Foundation
- Taishan Scholar Foundation of Shandong Province
- Qilu University of Technology
- Key Technology Research and Development Program of Shandong