Oral bacterial community dynamics during induction of gingival inflammation
This study concludes that occurrence of dental plaque and gingival bleeding are independent clinical parameters, linked to bacterial load and composition, respectively. Interactions between multiple niches, especially the tongue, influence clinical outcomes, highlighting a complex, nonlinear dynamic behavior in the oral microbiota. These findings suggest intricate ecological interactions that may approach tipping points, advancing understanding of microbial dynamics during gingival inflammation and informing future strategies for managing gingivitis.
Authors
- Bruno G. Loos (ORCID: https://orcid.org/0000-0002-8794-552X)
- Elena A. Nicu (ORCID: https://orcid.org/0000-0002-2443-0019)
- Remon Dulos
- Tim J. van den Broek
- NAM Rosema (ORCID: https://orcid.org/0000-0002-6708-6836)
- Bernd W. Brandt (ORCID: https://orcid.org/0000-0002-1155-1989)
- Bart J. F. Keijser (ORCID: https://orcid.org/0000-0003-1597-2948)
- Egija Zaura (ORCID: https://orcid.org/0000-0003-1432-6194)
- Ferry L P W Jagers
- Michelle van der Wurff
- Jolanda Kool
- Wim Crielaard
Institutions
- Netherlands Organisation for Applied Scientific Research (NL)
- Academic Center for Dentistry Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.3389/fcimb.2025.1597690
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health~Holland