Hydroxychloroquine enhances efferocytosis and modulates inflammation via MerTK/Gas6 signaling in a pristane-induced lupus mouse model
This study provides robust <i>in vitro</i> and <i>in vivo</i> evidence that HCQ promotes macrophage efferocytosis and anti-inflammatory reprogramming via MerTK/Gas6 signaling, offering insights into potential therapeutic mechanisms in SLE management.
Authors
- Chung‐Ming Huang (ORCID: https://orcid.org/0000-0003-4323-7115)
- Meng-Zhen Wu
- Hui‐Chen Chen (ORCID: https://orcid.org/0000-0001-9751-5729)
- Jun-Chieh James Tsay (ORCID: https://orcid.org/0000-0002-2282-2510)
- Fei-Hung Hsieh
- Gregory J. Tsay (ORCID: https://orcid.org/0000-0003-3817-8229)
- Shu-Yao Tsai
- Hen‐Hong Chang (ORCID: https://orcid.org/0000-0002-7840-1504)
- Yung‐Ju Yeh (ORCID: https://orcid.org/0000-0001-8263-1532)
- Shin-Yi Liu
- Chun-Ping Lin
- Ting-Yin Xue
- Weijing Li (ORCID: https://orcid.org/0000-0002-5860-0696)
- Ya-Wun Wu
Institutions
- Asia University (TW)
- China Medical University (TW)
- VA NY Harbor Healthcare System (US)
- China Medical University Hospital (TW)
- Pulmonary and Critical Care Associates (US)
- New York University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1524315
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.80