Sphingosine-1-phosphate stimulates colorectal cancer tumor microenvironment angiogenesis and induces macrophage polarization via macrophage migration inhibitory factor
By integrating multi-omics data and further cellular experiments, we propose that inhibition of S1P may play an important role in inhibiting angiogenesis and reversing M2-type macrophage polarization, demonstrating its anti-tumor efficacy in CRC.
Authors
- Jianhua Ren (ORCID: https://orcid.org/0000-0003-1109-8843)
- Binquan Wu (ORCID: https://orcid.org/0009-0008-5031-8339)
- Zhaode Feng
- Xuan Wang (ORCID: https://orcid.org/0000-0003-1844-0306)
- Yingcong Guo (ORCID: https://orcid.org/0000-0002-1661-5574)
- Fang Wu (ORCID: https://orcid.org/0000-0002-3177-1727)
- Shuheng Bai
- Ning Lan (ORCID: https://orcid.org/0000-0002-8447-9789)
- Min Chen
Institutions
- Inner Mongolia University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1564213
- Citations
- 6
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 4.78