Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy
Molecular pathways in plasma most consistently implicated in RHI were tied to immune response, mitochondrial function, and cell metabolism. RHI-related proteomic signatures tracked with antemortem cognitive severity and postmortem neuropathological burden, providing converging evidence for their role in disease progression. Differentially abundant proteins and co-expression modules in RHI may inform mechanisms linking RHI to increased dementia risk, thus guiding diagnostic biomarker and therapeutic development for at-risk populations.
Authors
- Jose F. Abisambra (ORCID: https://orcid.org/0000-0001-6341-679X)
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Breton M. Asken
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- Salvatore Spina (ORCID: https://orcid.org/0000-0003-3570-9143)
- Rowan Saloner (ORCID: https://orcid.org/0000-0002-1351-6183)
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Kaitlin Blackstone Casaletto (ORCID: https://orcid.org/0000-0001-5000-7604)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Leander Cornelis (ORCID: https://orcid.org/0000-0002-6594-9271)
- Sruti Rayaprolu (ORCID: https://orcid.org/0000-0002-5212-3745)
- William W. Seeley (ORCID: https://orcid.org/0000-0003-1410-2027)
- Paramita Chakrabarty (ORCID: https://orcid.org/0000-0002-6226-3776)
Institutions
- University of California, Santa Barbara (US)
- University of Florida (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s13024-025-00860-x
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Alzheimer's Association
- Larry L. Hillblom Foundation
- University of California, San Francisco
- National Institute on Aging