ScRNA-seq combined with ATAC-seq analysis to explore the metabolic balance mechanism of CCl4-induced liver inflammatory injury

Our findings contribute to the understanding of the evolution and underlying CCl4-induced inflammatory mechanisms governing hepatocyte inflammatory injury and the subsequent metabolic shift from imbalance toward balance under chronic CCl4 exposure, offering novel perspectives and directions for targeted therapeutic interventions in DILI.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-06-16
DOI
https://doi.org/10.3389/fimmu.2025.1600685
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

ScRNA-seq combined with ATAC-seq analysis to explore the metabolic balance mechanism of CCl4-induced liver inflammatory injury

Hui Liu, Shoubin Ning
Frontiers in Immunology
Liver Disease Diagnosis and Treatment
article

ScRNA-seq combined with ATAC-seq analysis to explore the metabolic balance mechanism of CCl4-induced liver inflammatory injury

Hui Liu, Shoubin Ning
article en

Abstract

Our findings contribute to the understanding of the evolution and underlying CCl4-induced inflammatory mechanisms governing hepatocyte inflammatory injury and the subsequent metabolic shift from imbalance toward balance under chronic CCl4 exposure, offering novel perspectives and directions for targeted therapeutic interventions in DILI.

Frontiers in ImmunologyVol. 16
United States Air Force (US), Air Force General Hospital PLA (CN), Shandong Provincial QianFoShan Hospital (CN)
Openalex Percentile: Top 80%
Liver Disease Diagnosis and Treatment
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