The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes
Overall, PEDV-induced intestinal damage, viral replication, and excretion were similar in studied groups regardless of viral strain or piglet age. The reduced clinical severity in weaned piglets may result from their stronger intestinal antiviral and pro-inflammatory response.
Authors
- H. Vorsholt
- N. Navarro (ORCID: https://orcid.org/0000-0002-2128-2292)
- Kerstin Skovgaard (ORCID: https://orcid.org/0000-0001-5663-4879)
- Carlos López-Figueroa
- Esmeralda Cano
- Rosa María López
- Joaquím Segalés (ORCID: https://orcid.org/0000-0002-1539-7261)
- Júlia Vergara‐Alert (ORCID: https://orcid.org/0000-0001-7484-444X)
- Peter M. H. Heegaard (ORCID: https://orcid.org/0000-0003-4506-4932)
- Maria Perez (ORCID: https://orcid.org/0009-0007-9188-759X)
Institutions
- Universitat Autònoma de Barcelona (ES)
- World Health Organization - Pakistan (PK)
- Centre de Recerca en Sanitat Animal (ES)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1584785
- Citations
- 1
- Primary Topic
- Viral gastroenteritis research and epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40