Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia
These findings indicate that LPS induces robust activation of pro-inflammatory OXL pathways with limited and transient engagement of pro-resolving lipid mediators. The imbalance may contribute to sustained or dysregulated inflammation. Our study provides novel insights into both systemic and adipocyte-specific OXL dynamics during endotoxemia and highlights their potential as biomarkers and therapeutic targets for modulating inflammation.
Authors
- A.L. Lock (ORCID: https://orcid.org/0000-0002-9282-399X)
- Madison N. Myers (ORCID: https://orcid.org/0000-0001-8567-8694)
- G. Andres Contreras (ORCID: https://orcid.org/0000-0003-4969-2178)
- Jair Parales-Girón (ORCID: https://orcid.org/0009-0001-2780-969X)
- Miguel Chirivi (ORCID: https://orcid.org/0000-0001-6604-2981)
- J.M. dos Santos Neto (ORCID: https://orcid.org/0000-0002-5335-8933)
- L C Worden (ORCID: https://orcid.org/0000-0002-2840-8302)
Institutions
- Michigan State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1595888
- Citations
- 1
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- U.S. Department of Agriculture
- Wayne State University
- Michigan State University
- Michigan Alliance for Animal Agriculture
- National Institutes of Health
- National Institute of Food and Agriculture
- College of Engineering, Michigan State University