Associations between metal exposure and metabolic syndrome: exploring the mediating role of biological ageing among US adults
This research employed multipollutant models including WQS regression, GWQS and BKMR to evaluate the combined effects of various metal exposures on the risk of developing MetS based on a nationally representative large cross-sectional study. In addition, this research investigated biological aging by conducting a comprehensive assessment of biological age and telomere length. Our goal is to understand its potential mediating effect on metal exposure and the occurrence of metabolic syndrome. The insights gained from this study could provide valuable hints for future mechanistic research in this field.
Authors
- Xingyan Xu (ORCID: https://orcid.org/0000-0002-4802-8542)
- Suping Luo (ORCID: https://orcid.org/0000-0003-3650-0165)
- Siying Wu (ORCID: https://orcid.org/0000-0003-3560-5678)
- Xinyue Lu (ORCID: https://orcid.org/0000-0002-0550-1141)
- Xiaoxu Xie (ORCID: https://orcid.org/0000-0002-3103-3724)
- Jianhui Guo (ORCID: https://orcid.org/0000-0001-5731-9328)
- Le Yang (ORCID: https://orcid.org/0000-0003-3707-2537)
- Ming‐Jun Chen (ORCID: https://orcid.org/0000-0002-1421-9498)
- Huangyuan Li
- Shaowei Lin
- Liuyan Zheng
Institutions
- Fujian Medical University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s13098-025-01784-8
- Citations
- 3
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 3.60
Funders
- National Natural Science Foundation of China