NET Proteomic Profiling Reveals New Pathways Potentially Implicated in Dendritic Cell-Mediated Inflammation in DADA2 Patients
We identified different pathways significantly modulated in DADA2 NETs versus PAN/HD NETs. This peculiar protein profile could contribute in activating inflammatory pathways in Dendritic cells in DADA2.
Authors
- Martina Bartolucci (ORCID: https://orcid.org/0000-0001-5289-4219)
- Francesca Schena (ORCID: https://orcid.org/0000-0002-5868-7699)
- Sara Signa (ORCID: https://orcid.org/0000-0002-9083-1726)
- Maurizio Bruschi (ORCID: https://orcid.org/0000-0001-6036-1500)
- Domenico Mavilio (ORCID: https://orcid.org/0000-0001-6147-0952)
- Arinna Bertoni (ORCID: https://orcid.org/0000-0001-8317-9584)
- Anna Corcione (ORCID: https://orcid.org/0000-0003-2439-1221)
- Alessia Cafaro (ORCID: https://orcid.org/0000-0003-1132-1267)
- Roberta Caorsi (ORCID: https://orcid.org/0000-0003-0131-7846)
- Dario Di Silvestre (ORCID: https://orcid.org/0000-0002-7143-6229)
- Stefano Volpi (ORCID: https://orcid.org/0000-0002-7129-868X)
- Silvia Della Bella (ORCID: https://orcid.org/0000-0003-0818-5049)
- Genny Del Zotto (ORCID: https://orcid.org/0000-0001-7272-7776)
- Stefania Croci (ORCID: https://orcid.org/0000-0002-8622-0439)
- Marco Gattorno (ORCID: https://orcid.org/0000-0003-0704-1916)
- Mariagrazia Catanoso (ORCID: https://orcid.org/0000-0002-4155-6094)
- Paola Bocca (ORCID: https://orcid.org/0000-0002-7498-209X)
- Antonella Insalaco (ORCID: https://orcid.org/0000-0003-1443-1840)
- Martina Bonacini (ORCID: https://orcid.org/0000-0002-6830-6781)
- Simone Balin (ORCID: https://orcid.org/0000-0002-5343-2523)
- Andrea Petretto (ORCID: https://orcid.org/0000-0001-7811-8517)
- Pierluigi Mauri (ORCID: https://orcid.org/0000-0003-4364-0393)
- Roberta Bertelli
- Andrea Lomagno (ORCID: https://orcid.org/0009-0007-5807-7827)
- Carlo Salvarani (ORCID: https://orcid.org/0000-0003-3708-3148)
- Gino Tripodi (ORCID: https://orcid.org/0000-0002-3259-4718)
- Lorenzo Pellottieri
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Milan (IT)
- Istituto Giannina Gaslini (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Institute of Biomedical Technologies (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1007/s10875-025-01888-w
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Novartis Pharma