Parasacral Transcutaneous Electrical Nerve Stimulation with Desmopressin Acetate for Treating Primary Monosymptomatic Enuresis: A Randomized Controlled Clinical Trial

Of 66 participants, 34 were randomized to the IG. The median age was 10.3 years (8.8 - 12), and 53% were male. Intention-to-treat analysis showed a significant reduction in the frequency of wet nights after the interventions (p < 0.001) in both groups, with the IG demonstrating significant improvement, immediately after the interventions (p=0.005) and after six months (p< 0.001) compared to the placebo group (PG). The Kaplan-Meier survival analysis showed improvement in the IG that became more pronounced from the 15th week onwards (log-rank test, p < 0.01). Conclusions: A 15-week treatment with desmopressin acetate and PTENS significantly reduced wet nights in children and adolescents with PMNE, and this improvement was maintained six months after the interventions.

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Publication Details

Journal
International braz j urol
Published
2025-08-18
DOI
https://doi.org/10.1590/s1677-5538.ibju.2025.0093
Primary Topic
Urinary Bladder and Prostate Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Parasacral Transcutaneous Electrical Nerve Stimulation with Desmopressin Acetate for Treating Primary Monosymptomatic Enuresis: A Randomized Controlled Clinical Trial

José de Bessa, Melissa Faria Dutra, Eleonora Moreira Lima, Gláucia Cristina Medeiros Dias et al.
International braz j urol
Urinary Bladder and Prostate Research
article

Parasacral Transcutaneous Electrical Nerve Stimulation with Desmopressin Acetate for Treating Primary Monosymptomatic Enuresis: A Randomized Controlled Clinical Trial

José de Bessa, Melissa Faria Dutra, Eleonora Moreira Lima, Gláucia Cristina Medeiros Dias, Lidyanne Ilídia da Silva de Paula, Flávia Cristina de Carvalho Mrad, José Murillo Bastos Netto, Mônica Maria de Almeida Vasconcelos, Amanda Gomes Pereira
article en

Abstract

Of 66 participants, 34 were randomized to the IG. The median age was 10.3 years (8.8 - 12), and 53% were male. Intention-to-treat analysis showed a significant reduction in the frequency of wet nights after the interventions (p < 0.001) in both groups, with the IG demonstrating significant improvement, immediately after the interventions (p=0.005) and after six months (p< 0.001) compared to the placebo group (PG). The Kaplan-Meier survival analysis showed improvement in the IG that became more pronounced from the 15th week onwards (log-rank test, p < 0.01). Conclusions: A 15-week treatment with desmopressin acetate and PTENS significantly reduced wet nights in children and adolescents with PMNE, and this improvement was maintained six months after the interventions.

International braz j urolVol. 51(5)
Universidade Federal de Juiz de Fora (BR), Universidade Federal de Minas Gerais (BR), Universidade Estadual de Feira de Santana (BR), Hospital das Clínicas da Universidade Federal de Minas Gerais (BR), Centro Universitário Academia (BR)
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Good health and well-being
Openalex Percentile: Top 81%
Urinary Bladder and Prostate Research
DOIOpen Access PDFOpenAlex
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