Comparative study of the efficacy of pre-treatment between intravenous lignocaine & ondansetron in prevention of pain due to intravenous injection of propofol

Background: Propofol, an anesthetic agent commonly used for medical procedures, is known to cause pain upon application to the skin due to its properties. Lignocaine and ondansetron are two agents that researchers have explored in advance to alleviate this pain. Objective: This study aims to evaluate the efficacy of ondansetron and 2% lignocaine in relieving pain during propofol injection. Methodology: The study was conducted as a prospective randomized double- blind controlled trial at the Department of Anaesthesiology and SICU, BIRDEM General Hospital, from May to November 2016. A total of 120 patients aged 18-50 years with ASA I-II status undergoing elective surgery were randomly assigned into three groups of 40, receiving either 2% lignocaine, 4 mg ondansetron, or normal saline before propofol administration. A tourniquet was applied after IV cannulation, pretreatment drugs were administered, and after 30 seconds, one-fourth of the propofol was injected over 10 seconds. Children were assessed for pain based on their behavior and facial expressions, as well as hemodynamic measures. All data were validated, stored appropriately, and analyzed using standard data analysis techniques, SPSS version 26. 0. Result: There were no significant differences in age, gender, ASA status, or socio-demographics among patients in the three groups, with average ages of 42.5, 35.6, and 37. 3 for groups A, B, and C, respectively. The majority of participants in the premedicated groups (62.5% in group B and 47.5% in group C) experienced slight or no pain, while none in group A reported such mild pain. Furthermore, group A recorded the highest number of reports of severe pain (27.5%), while groups B and C reported none. Patients in group A had higher pain scores (4.3.3) and heart rates (134 bpm), compared to the other groups (group B: 2. 2.9; group C: 3. 3.2; group A: 112 bpm). The premedicated groups (B and C) maintained their mean arterial pressure more consistently intraoperatively, suggesting improved hemodynamic stability. Conclusion: Recent studies indicate that the use of lignocaine or ondansetron following propofol injection helps relieve pain, maintain heart stability, and has minimal side effects.