Evaluation the antibacterial activity of Cornulaca moncantha extract against multidrug resistant coagulase- negative Staphylococci

Background: Emergence of anti-microbial resistance represents a serious challenge to public health and the global economy, creating an urgent need for searching of new anti-microbial agents. Objective: To investigate the antibacterial activity of Cornulaca moncantha ethanolic root extract against multidrug resistant coagulase-negative Staphylococci. Material and Methods: The ethanolic extract of Cornulaca moncantha roots was prepared using a Soxhalet apparatus. Phytochemical screening was performed via standard qualitative tests (alkaloids with Mayer’s test, tannins with ferric chloride, flavonoids with Shinoda test, and saponins with foam test). The plant antibacterial activity as well as susceptibility of antibiotic against bacteria were evaluated using agar well diffusion besides disc diffusion methods. Results: Phytochemical analysis revealed the presence of alkaloids, tannins and flavonoids in Cornulaca moncantha extract. The extract demonstrated potent antibacterial activity against bacteria compared to all tested antibiotics except vancomycin, exhibiting an inhibition zone of 22 mm versus vancomycin 20 mm. Notably, the antibiotic susceptibility test revealed that the bacteria were highly sensitive to vancomycin and resistant to other antibiotics. Conclusions: Cornulaca moncantha exhibited antibacterial activity and might serve as a potential candidate for controlling and treating infections caused by coagulase-negative Staphylococci.