Co-Crystallization: A technique to develop a better pharmaceutical formulatio

There are many potential drug molecules which cannot be used in formulation because of poor solubility, instability, poor bioavailability etc. To resolve these problems certain techniques such as salt formation, hydrates and Co-crystallization are used. Also, this technique is used to create multidrug co-crystals and in formulation of sustained release drug. Cocrystallization is very beneficial technique in order to gain patient of co-crystal of API molecule because of the novelty of the drug. This review article is about Co-crystallization; its method of preparation like Grinding method, Solvent evaporation technique, Slurry method, Antisolvent crystallization, Supercritical fluid processing; methods of characterization of co-crystals like Xray diffraction (XRD) studies, Differential scanning calorimetry, Spectroscopy, Field emission scanning electron microscopy (FESEM), Hot Stage Microscopy; its application in improving drug in various aspect, advantage, and limitations.