Synaptic Vesicle Glycoprotein 2A Slows down Amyloidogenic Processing of Amyloid Precursor Protein <i>via</i> Regulating Its Intracellular Trafficking.
These results demonstrated that SV2A promotes APP transport from the TGN to early endosomes by upregulating Arl5b and promoting APP transport from early endosomes to recycling endosomes-cell membrane pathway, which slows APP amyloid degradation.
Authors
- Cong Cong Liu
- Qian Zhang (ORCID: https://orcid.org/0000-0003-3982-8270)
- Yu Li Hou
- Jing Liu (ORCID: https://orcid.org/0000-0002-3311-0818)
- Pei Chang Wang
- Ya Qi Wang
- Song Qiao
- Xiao Min Zhang (ORCID: https://orcid.org/0000-0001-6596-2233)
- Junting Liu (ORCID: https://orcid.org/0000-0003-3912-9568)
- Yu Fan
- Jing Jing Zhang (ORCID: https://orcid.org/0000-0002-5293-1267)
- Xiao Ling Wang
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3967/bes2025.049
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00