[Identifying genetic etiology of ischemic stroke based on pleiotropy of obesity related genes: A sibling study].
Pleiotropy between BMI-related genes and IS was observed. Forty-five SNPs were found with linkage and association with IS in the pleiotropy gene set and mapped to 40 genes, which were functionally enriched in lipid metabolic pathways. The rs2232852 corrected by multiple tests during association analysis validation was mapped to <i>CYB5R1</i> and <i>ADIPOR1</i>, which were related to lipid metabolism and the ferroptosis pathway, suggesting that lipid metabolism and ferroptosis played an important role in the development of IS.
Authors
- Xianhui Qin (ORCID: https://orcid.org/0000-0001-7812-7982)
- Yiqun Wu (ORCID: https://orcid.org/0000-0002-5554-1678)
- Liwei Zheng (ORCID: https://orcid.org/0000-0002-0467-1720)
- Hao Yu (ORCID: https://orcid.org/0000-0002-9785-8489)
- Dafang Chen (ORCID: https://orcid.org/0000-0001-8226-5413)
- Rui Yang (ORCID: https://orcid.org/0000-0003-2291-4914)
- Huijun Wang (ORCID: https://orcid.org/0000-0001-5414-1472)
- Kai You Wang (ORCID: https://orcid.org/0000-0002-6170-4744)
- Jian Wu (ORCID: https://orcid.org/0000-0002-3394-1507)
- Tao Wu (ORCID: https://orcid.org/0000-0001-9456-4082)
- Yonghua Hu
Institutions
- Peking University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-06-18
- DOI
- https://doi.org/10.19723/j.issn.1671-167x.2025.03.007
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article