The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12‐month randomized trial
Evidence suggests that exercise may delay Alzheimer's disease (AD) in the general population, but its impact on adults with Down syndrome (DS) remains unknown.Adults attended remote exercise sessions either 1 or 3 times a week or received basic education about exercise.Those who attend exercise sessions 3 times a week increased their physical activity by 70 min per week.Those who attend exercise sessions 3 times a week improve their cardiorespiratory fitness.Remote exercise can be used in future AD prevention trials in adults with DS.
Authors
- Lauren T. Ptomey (ORCID: https://orcid.org/0000-0002-1705-1643)
- Anna M. Gorczyca (ORCID: https://orcid.org/0000-0002-9689-7646)
- Brian C. Helsel (ORCID: https://orcid.org/0000-0003-3362-3581)
- Ron Krebill (ORCID: https://orcid.org/0000-0002-8405-4860)
- Richard A. Washburn (ORCID: https://orcid.org/0000-0002-8484-0669)
- Jessica C. Danon
- Joseph R. Sherman
- Joseph E. Donnelly (ORCID: https://orcid.org/0000-0002-6502-8069)
- Amanda N. Szabo‐Reed (ORCID: https://orcid.org/0000-0002-4927-1501)
- Daniel Forsha (ORCID: https://orcid.org/0000-0003-1999-6509)
- Robert N. Montgomery (ORCID: https://orcid.org/0000-0002-1423-0590)
- Amy E. Bodde (ORCID: https://orcid.org/0000-0002-8143-8105)
Institutions
- Children's Mercy Hospital (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70115
- Citations
- 1
- Primary Topic
- Chronic Disease Management Strategies
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Institute on Aging
- National Institute of General Medical Sciences