Genetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease
ANA+ occurring in the absence of autoimmune disease has a genetic association with the <i>HLA</i> region, but overall heritability is low. In addition, few SLE-associated SNPs were associated with ANA+, and the PRS for SLE was not associated with ANA+, indicating limited genetic overlap.
Authors
- Jacy Zanussi
- Atlas Khan (ORCID: https://orcid.org/0000-0002-6651-2725)
- Frank Mentch (ORCID: https://orcid.org/0000-0003-4889-6961)
- Nancy J. Olsen (ORCID: https://orcid.org/0000-0002-6588-3364)
- Nancy Jean Cox (ORCID: https://orcid.org/0000-0001-9315-0830)
- Krzysztof Kiryluk (ORCID: https://orcid.org/0000-0002-5047-6715)
- Scott J. Hebbring (ORCID: https://orcid.org/0000-0003-2369-153X)
- Gul Karakoc
- Vivian K. Kawai (ORCID: https://orcid.org/0000-0001-5841-2575)
- Mingjian Shi (ORCID: https://orcid.org/0000-0003-1569-9822)
- Ge Liu
- Jonathan D. Mosley (ORCID: https://orcid.org/0000-0001-6421-2887)
- Charles Stein
- James G. Linneman
- Wei-Qi Wei
Institutions
- Children's Hospital of Philadelphia (US)
- University of Alabama at Birmingham (US)
- Marshfield Clinic (US)
- Columbia University (US)
- Penn State Milton S. Hershey Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Lupus Science & Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/lupus-2024-001476
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arthritis National Research Foundation
- Children's Hospital of Philadelphia
- Vanderbilt University
- Northwestern University
- Cincinnati Children's Hospital Medical Center
- University of Washington
- Lupus Research Alliance
- Vanderbilt University Medical Center
- Broad Institute
- Georgia Clinical and Translational Science Alliance
- King's College London
- National Research Foundation
- National Institutes of Health
- National Human Genome Research Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases