Stage‐Dependent Inhibitory Connectivity in Striatal‐Motor Circuit in Huntington's Disease
Our results indicate that striatal atrophy and hyper-inhibition of caudate-motorial connectivity might contribute to the regional function alterations in HD. Furthermore, disruption of inhibitory connectivity in the striatal-motor circuit may play an important role in the emergence of motor symptoms.
Authors
- Imis Dogan (ORCID: https://orcid.org/0000-0002-6632-197X)
- Rena Overbeck
- Sandro Romanzetti (ORCID: https://orcid.org/0000-0001-8519-1309)
- Kathrin Reetz (ORCID: https://orcid.org/0000-0002-9730-9228)
- Yinghua Jing (ORCID: https://orcid.org/0000-0001-5387-6063)
Institutions
- Jülich Aachen Research Alliance (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-06-12
- DOI
- https://doi.org/10.1002/acn3.70104
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00