Ruthenium Oxide Nanozyme for Tendinopathy Treatment via Countering Ferroptosis

The global prevalence of tendinopathy (TP) is steadily increasing, resulting in functional impairments in tendons across individuals of all ages. Excessive accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of TP, which compromises tendon repair and integrity through oxidative stress. This process is often accompanied by ferroptosis-a newly recognized form of iron-dependent programmed cell death. This study explores ruthenium oxide (RuO<sub>2</sub>) hollow nanospheres as an effective nanozyme to address oxidative damage and ferroptosis in type I collagenase-induced TP. In vitro experiments show decreased mRNA levels of inflammatory biomarkers in tenocytes, while western blot analysis and immunofluorescence reveal reduced extracellular matrix degradation after RuO<sub>2</sub> treatment. In the TP model, the RuO<sub>2</sub> nanozyme therapy and improves tendon fiber arrangement, alleviates pain, and increases type I collagen expression while preventing matrix degradation. These findings suggest that the RuO<sub>2</sub> nanozyme possesses significant antioxidant and anti-inflammatory properties, providing protective effects on tenocytes by ROS scavenging and countering ferroptosis, indicating its potential for treating TP.

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Publication Details

Journal
Advanced Healthcare Materials
Published
2025-06-12
DOI
https://doi.org/10.1002/adhm.202501035
Citations
2
Primary Topic
Extracellular vesicles in disease
Type
article
Field-Weighted Citation Impact
1.61

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article

Ruthenium Oxide Nanozyme for Tendinopathy Treatment via Countering Ferroptosis

Muhammad Faheem, C. F. Qiao, Zhihao Lu, Hui Wei et al.
2 citations
Advanced Healthcare Materials
Extracellular vesicles in disease
1.61
article

Ruthenium Oxide Nanozyme for Tendinopathy Treatment via Countering Ferroptosis

Muhammad Faheem, C. F. Qiao, Zhihao Lu, Hui Wei, Nirong Bao, Yuxiang Fei, Hanwen Zhang, Nuo Xu, Xiquan Cheng, Zhaofeng Zhang, Chenguang Lin, Xiang Gu, Ya Xie, Wenli Gong, Yuan Liu, Jintao Lin, Dongquan Shi, Jia Meng, Xiaojiang Yang, Chunqing Hu, Zhongyang Lv, Jie Lv, Ziying Sun, Haoyu Yang, Ruiyang Jiang, Zheng Wang
article en
2 citations

Abstract

The global prevalence of tendinopathy (TP) is steadily increasing, resulting in functional impairments in tendons across individuals of all ages. Excessive accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of TP, which compromises tendon repair and integrity through oxidative stress. This process is often accompanied by ferroptosis-a newly recognized form of iron-dependent programmed cell death. This study explores ruthenium oxide (RuO<sub>2</sub>) hollow nanospheres as an effective nanozyme to address oxidative damage and ferroptosis in type I collagenase-induced TP. In vitro experiments show decreased mRNA levels of inflammatory biomarkers in tenocytes, while western blot analysis and immunofluorescence reveal reduced extracellular matrix degradation after RuO<sub>2</sub> treatment. In the TP model, the RuO<sub>2</sub> nanozyme therapy and improves tendon fiber arrangement, alleviates pain, and increases type I collagen expression while preventing matrix degradation. These findings suggest that the RuO<sub>2</sub> nanozyme possesses significant antioxidant and anti-inflammatory properties, providing protective effects on tenocytes by ROS scavenging and countering ferroptosis, indicating its potential for treating TP.

Advanced Healthcare MaterialsVol. 14(21)
Nanjing University of Chinese Medicine (CN), Shenzhen University (CN), Nanjing General Hospital of Nanjing Military Command (CN), Soochow University (CN), Nanjing Drum Tower Hospital (CN), Wuxi Ninth People's Hospital (CN), Collaborative Innovation Center of Advanced Microstructures (CN), Wuxi People's Hospital (CN), Nanjing University (CN)
National Natural Science Foundation of China, China Postdoctoral Science Foundation
Openalex Percentile: Top 17%
Extracellular vesicles in disease
1.61
DOISourceOpenAlex
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