Electrochemical Oxidative [3 + 2] Annulation of <i>p</i> ‐Methoxy Anilines with Enaminones toward 3‐Acyl Indoles
An electrochemical oxidative [3 + 2] annulation of p ‐methoxy anilines with enaminones is reported. This protocol enables facile synthesis of 3‐acyl indoles in moderate to good yields under mild conditions, featuring excellent functional group tolerance, operational simplicity, and gram‐scale scalability. Based on the cyclic voltammetry and control experiments, a plausible mechanism involving the aniline radical pathway is proposed.
Authors
- Caipeng Wang
- Pei Guan
- Yongfang Wang
- Jindian Duan (ORCID: https://orcid.org/0000-0002-8378-8651)
- Luchao Li
- Kai Guo (ORCID: https://orcid.org/0000-0002-0013-3263)
- Delong Ma (ORCID: https://orcid.org/0000-0002-5669-369X)
- Fang Zheng (ORCID: https://orcid.org/0000-0002-5369-0899)
- Lu Deng (ORCID: https://orcid.org/0000-0002-3026-4205)
- Yan Meng (ORCID: https://orcid.org/0009-0001-0185-4193)
Institutions
- Nanjing Tech University (CN)
- Liaocheng People's Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-06-12
- DOI
- https://doi.org/10.1002/adsc.9597
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China