Rh(<scp>iii</scp>)-catalyzed annulation of oxadiazolones with CF<sub>3</sub>-imidoyl sulfoxonium ylides: access to trifluoromethyl-substituted fused-dihydroisoquinolines
A rhodium(III)-catalyzed redox-neutral C(sp<sup>2</sup>)-H bond activation and annulation of oxadiazolones and CF<sub>3</sub>-substituted imidoyl sulfoxonium ylides (TFISYs) has been developed. A cascade C(sp<sup>2</sup>)-H bond imidoylmethylation and subsequent intramolecular nucleophilic addition sequence might be involved in the transformation, providing direct access to diverse trifluoromethyl and amino-containing fused-dihydroisoquinolines.
Authors
- Zhengkai Chen (ORCID: https://orcid.org/0000-0002-5556-6461)
- Qihua Chen (ORCID: https://orcid.org/0000-0002-2813-7485)
- Sihao Ling
Institutions
- Zhejiang Sci-Tech University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00732a
- Citations
- 6
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.62